Classical
Genetics Objectives
Upon
completion of this unit the student will be able to:
1.
list several features of Mendel's methods that contributed to his success.
2. list and explain Mendel's laws of heredity
3. use a Punnett square to predict the results of a monohybrid cross and state the phenotypic and genotypic ratios of the F2 generation.
4. distinguish between genotype and phenotype; heterozygous and homozygous; dominant and recessive.
5. explain how a testcross can be used to determine if a dominant phenotype is homozygous or heterozygous.
6. state Mendel's law of independent assortment.
7. use a Punnett square to predict the results of a dihybrid cross and state the phenotypic and genotypic ratios of the F2 generation.
8. using the laws of probability, predict the results of dihybrid and trihybrid crosses.
9. state several; examples of incomplete dominance and explain this it is not evidence for the blending theory of inheritance.
10. explain how the phenotypic expression of the heterozygote is affected by complete dominance, incomplete dominance and codominance.
11. describe the inheritance of the ABO blood system and explain why the IA and IB alleles are said to be codominant.
12. define and give examples of pleiotropy.
13.. explain the term epistasis.
14. explain how epistasis affects the phenotypic ratio for a dihybrid cross.
15. describe a simple model for polygenic inheritance, and explain why most polygenic characters are described in quantitative terms.
16. describe how environmental conditions can influence the phenotypic expression of a character.
17. given a simple family pedigree, deduce the genotypes for some of the family members.
18. describe the inheritance and expression of cystic fibrosis, Tay-Sachs disease, and sickle-cell disease.
19. explain how a lethal recessive gene can be maintained in a population.
20. explain why consanguinity increases the probability of homozygosity in offspring.
21. explain why lethal dominant genes are much more rare than lethal recessive genes.
22. give an example of a late-acting lethal dominant in humans and explain how it can escape elimination.
23. explain how carrier recognition, fetal testing and newborn screening can be used in genetic screening and counseling.
24. explain why Drosophila melanogaster is a good experimental organism.
25. discuss linkage and explain why linkage interferes with independent assortment.
26. explain how crossing over can unlink genes.
27. map a linear sequence of genes on a chromosome using given recombination frequencies from experimental crosses.
28. describe sex determination in humans.
29. describe the inheritance of a sex-linked gene such as color-blindness or hemophilia
30. explain why a recessive sex-linked gene is always expressed in human males.
31. explain the difference between deletion, translocation, and inversion mutations..
32. distinguish among deletions, duplications, translocations, and inversions.
33. explain why cytoplasmic genes are not inherited in a Mendelian fashion.
2. list and explain Mendel's laws of heredity
3. use a Punnett square to predict the results of a monohybrid cross and state the phenotypic and genotypic ratios of the F2 generation.
4. distinguish between genotype and phenotype; heterozygous and homozygous; dominant and recessive.
5. explain how a testcross can be used to determine if a dominant phenotype is homozygous or heterozygous.
6. state Mendel's law of independent assortment.
7. use a Punnett square to predict the results of a dihybrid cross and state the phenotypic and genotypic ratios of the F2 generation.
8. using the laws of probability, predict the results of dihybrid and trihybrid crosses.
9. state several; examples of incomplete dominance and explain this it is not evidence for the blending theory of inheritance.
10. explain how the phenotypic expression of the heterozygote is affected by complete dominance, incomplete dominance and codominance.
11. describe the inheritance of the ABO blood system and explain why the IA and IB alleles are said to be codominant.
12. define and give examples of pleiotropy.
13.. explain the term epistasis.
14. explain how epistasis affects the phenotypic ratio for a dihybrid cross.
15. describe a simple model for polygenic inheritance, and explain why most polygenic characters are described in quantitative terms.
16. describe how environmental conditions can influence the phenotypic expression of a character.
17. given a simple family pedigree, deduce the genotypes for some of the family members.
18. describe the inheritance and expression of cystic fibrosis, Tay-Sachs disease, and sickle-cell disease.
19. explain how a lethal recessive gene can be maintained in a population.
20. explain why consanguinity increases the probability of homozygosity in offspring.
21. explain why lethal dominant genes are much more rare than lethal recessive genes.
22. give an example of a late-acting lethal dominant in humans and explain how it can escape elimination.
23. explain how carrier recognition, fetal testing and newborn screening can be used in genetic screening and counseling.
24. explain why Drosophila melanogaster is a good experimental organism.
25. discuss linkage and explain why linkage interferes with independent assortment.
26. explain how crossing over can unlink genes.
27. map a linear sequence of genes on a chromosome using given recombination frequencies from experimental crosses.
28. describe sex determination in humans.
29. describe the inheritance of a sex-linked gene such as color-blindness or hemophilia
30. explain why a recessive sex-linked gene is always expressed in human males.
31. explain the difference between deletion, translocation, and inversion mutations..
32. distinguish among deletions, duplications, translocations, and inversions.
33. explain why cytoplasmic genes are not inherited in a Mendelian fashion.
Videos:
Genotypes and Phenotypes -
http://www.bozemanscience.com/science-videos/2011/9/14/033-genotypes-and-phenotypes.html
Mendelian Genetics -
http://www.bozemanscience.com/science-videos/2011/9/14/029-mendelian-genetics.html
Non-Mendelian Genetics -
http://www.bozemanscience.com/science-videos/2011/9/14/030-advanced-genetics.html
Genotype Expression -
http://www.bozemanscience.com/science-videos/2012/2/19/053-genotype-expression.html
Mechanisms of Genetic Variation -
http://www.bozemanscience.com/science-videos/2011/9/14/034-mechanisms-the-increase-genetic-variability.html
WS:
Guided Notes Sheet
Genetics Practice Packet
Mendelian Genetics Packet
Drosphilia Simulation Packet
Additional Items:
Chromosome Viewer -
http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/chooser.shtml
Genes and Blood Types -
http://learn.genetics.utah.edu/content/begin/traits/blood/
Genetics Prezi Reviews
Genetics 1 -
http://prezi.com/jousblqvrtns/ap-bio-mendelian-genetics-1-intro-to-mendelian-genetics/
Genetics 2 -
http://prezi.com/zphgne1krrqo/ap-bio-mendelian-genetics-2-extensions-to-mendelian-genetics/
Genetics 3 -
http://prezi.com/bpqviw0m4jjk/ap-bio-mendelian-genetics-3-human-genetic-conditions/
